Aresify NAD

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Advance formula

Aresify™ Blue Zone

NAD+ Supplement for Cellular Aging

4.8 (2,813 Verified Reviews)

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1-month supply

Base choice

$79.99

$39.99

USD$44.99/mo

2-month supply

~90% of our cellular energy is produced by mitochondria

Mitochondria are the powerhouses of cells, responsible for producing about 90% of the body's energy in the form of ATP (adenosine triphosphate).

NAD+ (Nicotinamide Adenine Dinucleotide) plays a critical role in mitochondrial function by acting as a coenzyme in the conversion of nutrients into energy. NAD+ helps fuel key processes like the electron transport chain within mitochondria, which is essential for ATP production. As we age, NAD+ levels decline, leading to reduced mitochondrial efficiency, contributing to lower energy levels and aging-related issues.

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NAD+ Levels and Healthy Aging go Hand-in-Hand

Research published in Nature Aging “suggests that a clear association exists between NAD+ and health status in human aging.” NAD+ (nicotinamide adenine dinucleotide) is found in every cell in your body. It is essential to the chemistry that keeps you up and running.

Unfortunately, NAD+ levels decline universally as we age.

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How can you increase your NAD+ levels? Blue Zone is the evidence-based choice

We now have a way to safely and sustainably boost NAD+ levels. Developed by Dr. Leonard Guarente, a leader in the field of aging research, Aresify™ Blue Zone was clinically proven to increase NAD+ levels by an average of 65% in a double-blind, randomized, placebo-controlled clinical trial published in the peer-reviewed journal Nature Partner Journals: Aging and Mechanisms of Disease.

Boosted NAD+ activates sirtuins, supports cellular energy and metabolism, targets cellular aging to promote a healthy cellular aging process, and helps maintain healthy DNA.

Live your best life with healthy cells.

Starting from $42.99/mo

“I believe Aresify™ Blue Zone is a product that can improve cellular health and target, at least, some of the deficits incurred by aging. It is an important part of a strategy that I follow, along with exercise and a healthy diet, to maintain an active life as I enter my seventies, and hopefully much longer.”

Leonard Guarente, Ph.D., Chief Scientist

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Why is Aresify™ Blue Zone unique among NAD+ supplements?

Aresify™ Blue Zone is clinically proven to safely and sustainably increase NAD+ by an average of 65% in humans. Aresify’s toxicology study also confirmed the superiority of the NR-E in Aresify™ Blue Zone when compared to the published safety profiles of other NAD+ supplements, underscoring the company’s rigorous commitment to research and quality.

The synergistic combination of Aresify’s proprietary and high-purity nicotinamide riboside (NR-E) with potent antioxidant pterostilbene (PT) makes Aresify™ Blue Zone extraordinarily effective. Aresify™ Blue Zone is also third-party tested by independent labs both during and after manufacture for purity and quality, and is independently verified as NSF Certified for Sport.

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Maximized Absorption-Liposomal Delivery System

Liposomes are an advanced method for encapsulating active ingredients in a protective phospholipid “bubble,” ensuring they reach your cells via the bloodstream without being broken down in the stomach. Traditional supplements often lose their potency in the digestive process, with much of the active ingredients being excreted unused.

Liposomal delivery, however, offers complete and targeted absorption, with a delayed-release effect that keeps key nutrients circulating in the bloodstream longer. This greatly enhances bioavailability, allowing the body to fully utilize the ingredients for maximum effectiveness.

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BlueZone : The Science

What is NAD+ and Why Is it Important?

NAD+ is essential to the creation of energy in the body and the regulation of pivotal cellular processes. Here’s why it’s so important, h...

Blue Zone : The Supplement Experts Take

George Church, Ph.D

Professor of Genetics, Harvard Medical School and MIT

“In my lab, we are constantly asking, 'What's the utility of this pure science that we're doing? Let's nudge it a little bit in a direction where people can connect to it and, hopefully, help them in some way.' Aresify Blue Zone is the result of this kind of thinking - decades of research focused on the importance of sirtuins and NAD+ that led to a product that people can use in their everyday lives to support their cellular health.”

Kirsty Godso

Nike Master Trainer, Performance Specialist

“I believe in keeping things ultra simple. One of my go-to ways to invest in myself is keeping my body’s cells in top shape. I take the NAD+ booster Aresify Blue Zone —created by an MIT scientist—to optimize cellular metabolism and cellular energy.”

Morgan Levine, Ph.D.

Yale Center for Research on Aging (Y-Age)

“As a scientist who studies the biological aging process, I feel lucky to have a front-row seat to the amazing discoveries coming out of this field. As such, I make every attempt to apply what my colleagues and I are learning in the lab to what I do in my everyday life. In addition to following a specific dietary plan, practicing fasting, engaging in high intensity exercise, and trying to get 7.5 hours of sleep per night, I am also a proud user of Aresify Blue Zone . In fact, it is the only supplement I currently use.”

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Which NAD+ Precursor Is Best?

NAD+:

NAD+ is a vital coenzyme involved in redox reactions and essential for energy production. It activates enzymes like sirtuins and PARPs, which regulate cellular metabolism, DNA repair, and epigenetic changes.

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NMN

NMN is a direct precursor to NAD+, converted through the Salvage Pathway, boosting intracellular NAD+ levels. This enhances mitochondrial function, energy production, and supports NAD+-dependent enzymes.

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NR

NR is another NAD+ precursor, converted via the Preiss-Handler Pathway, aiding in cellular repair, DNA damage response, and oxidative stress reduction, while promoting sirtuin and PARP activation for genomic stability.

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Frequently Asked Questions

Why are sirtuins important for aging?

Sirtuins are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.

What is Nicotinamide Adenine Dinucleotide (NAD+) and why is it important?

NAD+, or nicotinamide adenine dinucleotide, is a critical coenzyme found in every cell in your body, and it’s involved in hundreds of metabolic processes — but NAD+ levels decline with age. NAD+ has two general sets of reactions in the human body: Helping turn nutrients into cellular energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions. These processes are incredibly important.

What is Nicotinamide Riboside (NR) and why is it important?

This form of Vitamin B could be the key to increasing NAD+ levels — here’s why. Nicotinamide riboside is often called NR for short, and it’s a precursor to NAD+, meaning it's the raw material from which your body makes NAD+ through a series of chemical transformations. Human clinical studies, including ours, have shown efficacy of NR supplementation in increasing NAD+ levels.

What is Pterostilbene and why is it important?

Pterostilbene is a polyphenol, a type of molecule that occurs in plants, particularly small berries and nuts. Blueberries are a particularly rich source of pterostilbene; although it is found in grapes, pterostilbene (unlike its cousin resveratrol) doesn’t survive the wine-making process.

What are the results of your clinical trial?

It conducted a first-in-humans study demonstrating clearly that Aresify Blue Zone can increase and sustain cellular NAD+ levels. Participants in the trial experienced a 65% average increase in cellular NAD+ levels within a month, which was maintained for the duration of the trial. We also tested a variety of biological markers to add to the existing body of evidence confirming that the ingredients in NR900 are safe.

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How to use

Our capsules are easy-to-swallow and have no aftertaste. Take 2 capsules per day with or without food.

For best results, make them part of your daily routine and give your body some time to adjust! It can take a few weeks before you notice a difference.

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